Epigenetics

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

The gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized. Knowledge …

Juan L. Mateo, Debbie L.C. van den Berg, Maximilian Haeussler, Daniela Drechsel, Zachary B. Gaber, Diogo S. Castro, Paul Robson, Q. Richard Lu, Gregory E. Crawford, Paul Flicek, Laurence Ettwiller, Joachim Wittbrodt, François Guillemot, Ben Martynoga

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling …

Ben Martynoga, Juan L. Mateo, Bo Zhou, Jimena Andersen, Angeliki Achimastou, Noelia Urbán, Debbie van den Berg, Dimitra Georgopoulou, Suzana Hadjur, Joachim Wittbrodt, Laurence Ettwiller, Michael Piper, Richard M. Gronostajski, François Guillemot