Bioinformatics

Loss of NFIX Transcription Factor Biases Postnatal Neural Stem/Progenitor Cells Toward Oligodendrogenesis
Murine postnatal neural stem cells (NSCs) give rise to neurons, astrocytes, or oligodendrocytes (OLs); however, our knowledge of the …
PDF DOI
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Engineering of the CRISPR/Cas9 system has opened a plethora of new opportunities for site-directed mutagenesis and targeted genome …
PDF Code DOI CCTop
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal
The gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized. Knowledge …
PDF DOI
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence
The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling …
PDF DOI